Radiotherapy, a common therapeutic presidium in the Oncological field, has as one of its most common cutaneous toxic effects the radiodermite. In fact, 85% of patients subjected to radiotherapy develop cutaneous manifestations ranging from the moderate erythematous rash to the actual ulceration.
When this procedure is also associated with a chemotherapy-type protocol, the skin lesions may add ‘ recall ‘ reactions and ‘ increase ‘ reactions (radiation enhancement).
Radiation recall refers to the cutaneous phenomenon for which after the administration of chemotherapy (e.g., a taxa) an inflammatory reaction is induced in a previously irradiated area.
It is a erythematous eruption that is variablely associated with blistering, flaking and itching.
Radiation enhancement refers to the increase in skin toxicity produced by radiotherapy and caused by the administration of a chemotherapy at the same time or at a distance of about 7 days from radiotherapy.
The drugs that are most frequently involved in this reaction are: bleomycin, doxorubicin, Fluorurabile, Hydroxyurea, 6-mercaptopurine and methotrexate.
Clinically it presents as a radiodermite with erythema, edema, vesicles, blisters or erosion, in severe cases tissue necrosis that, unlike the radiation recall, can extend locally beyond the irradiated area.
Both manifestations are resolved in a matter of months, but are extremely disabling as long-term can lead to cutaneous atrophy, fibrotic and Telangiectasias.
Finally, it is possible that there is a flare or even a first onset of radiodermite, as a result of fairly frequent and common situations, ranging from simple fever to reactions as a result of radiological examinations of control such as TAC, Mammography, chest RX.
Dermocosmetologico protocol for Radiodermite
Radiodermite is usually shown when the skin is exposed to dosages higher than 2000cGy, while dryness associated with flaking and itching is a frequent occurrence.
The rules of cleansing and hydration described in the Dermocosmetologico protocol are also valid here.
The dosage of use involves the application of the cosmetic Presidium immediately before and immediately after exposure to radiotherapy. Of particular interest is a new series of antioxidants combined with the real dedicated cosmetics: Rusco, Red Vine, Ubidecanone, Q10, extracts of particular marine algae.